Determination of VOCs in Surgical Resected Tissues from Colorectal Cancer Patients by Solid Phase Microextraction Coupled to Gas Chromatography–Mass Spectrometry

Early diagnosis of colorectal cancer is crucial to increase the survival rates patients and breath analysis represents a promising non-invasive tool obtain information on cancer-related variations human volatilome. A solid phase microextraction coupled gas chromatography–mass spectrometry method for determination seven selected compounds, representative volatilome secreted by colonic mucosa affected cancer, including benzaldehyde, benzoic acid, dodecane, ethylbenzene, octanal, tetradecane toluene, was developed. All extraction parameters were studied both headspace direct immersion sampling procedures fully validated. The potential approach demonstrated time monitoring emission volatile organic compounds from surgical resected colon tissues patients. Furthermore, identification thirty-one same accomplished.